<i>In vitro</i> Antibacterial Effect of Polyglycerol Monolaurates against Gram-Bacteria and Understanding the Underlying Mechanism

Polyglycerol monolaurates are generally recognized as safe food additives and commonly used emulsifiers. In this study, the antimicrobial effect of four polyglycerol on two Gram-positive bacteria (Staphylococcus aureus Bacillus subtilis) Gram-negative (Escherichia. coli Pseudomonas aeruginosa) were investigated. The minimum inhibitory concentration (MIC) diglycerol monolaurate (PG2ML), triglycerol (PG3ML), hexaglycerol (PG6ML), decaglycerol (PG10ML) against S. was 0.16, 0.32, 0.63, 1.25 mg/mL, respectively. MIC PG2ML, PG3ML, PG6ML, PG10ML B. subtilis 1.25, 3.75 No apparent these E. P. aeruginosa observed even up to 10.00 mg/mL. underlying mechanism investigated by assessing cell membrane permeability, integrity membrane, morphology. We concluded that might eliminate disrupting thereby increasing releasing cellular contents, altering